Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice

Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activity. Lack of PAX7 acetylation reduces DNA binding,...

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Publicat a:Nat Commun
Autors principals: Sincennes, Marie-Claude, Brun, Caroline E., Lin, Alexander Y. T., Rosembert, Tabitha, Datzkiw, David, Saber, John, Ming, Hong, Kawabe, Yoh-ichi, Rudnicki, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167170/
https://ncbi.nlm.nih.gov/pubmed/34059674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23577-z
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