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Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice
Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activity. Lack of PAX7 acetylation reduces DNA binding,...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8167170/ https://ncbi.nlm.nih.gov/pubmed/34059674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23577-z |
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