Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells

Compensatory growth and regeneration of skeletal muscle is dependent on the resident stem cell population, satellite cells (SCs). Self-renewal and maintenance of the SC niche is coordinated by the paired-box transcription factor Pax7, and yet continued expression of this protein inhibits the myoblas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dick, Sarah A., Chang, Natasha C., Dumont, Nicolas A., Bell, Ryan A. V., Putinski, Charis, Kawabe, Yoichi, Litchfield, David W., Rudnicki, Michael A., Megeney, Lynn A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586827/
https://ncbi.nlm.nih.gov/pubmed/26372956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512869112
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