Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells

Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells (MSCs). However, the biological function of chaperone-mediated autophagy (CMA) in MSCs remains elusive. Here, we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines in...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Zhang, Jie, Huang, Jiefang, Gu, Yuting, Xue, Mingxing, Qian, Fengtao, Wang, Bei, Yang, Wanlin, Yu, Hongshuang, Wang, Qiwei, Guo, Xin, Ding, Xinyuan, Wang, Jina, Jin, Min, Zhang, Yanyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167126/
https://ncbi.nlm.nih.gov/pubmed/31900460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0345-7
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