The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase

Rationale: Resistance to pemetrexed (PEM)-based chemotherapy is a major cause of progression in non-small cell lung cancer (NSCLC) patients. The deubiquitinating enzyme UCHL1 was recently found to play important roles in chemoresistance and tumor progression. However, the potential roles and mechani...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Ding, Xinyuan, Gu, Yuting, Jin, Min, Guo, Xin, Xue, Sudong, Tan, Caihong, Huang, Jiefang, Yang, Wanlin, Xue, Mingxing, Zhou, Qianjun, Wang, Wenjuan, Zhang, Yanyun
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255002/
https://ncbi.nlm.nih.gov/pubmed/32483437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.42096
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