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RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor
The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation and contributes to the pathogenesis of multiple autoinflammatory, metabolic and neurodegenerative diseases, but medications targeting the NLRP3 inflammasome are not available for clinical use. RRx-001 is a well-tolera...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Mol Immunol |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8166941/ https://ncbi.nlm.nih.gov/pubmed/33972740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-021-00683-y |
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