Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome activation, but compounds directly and specifically targeting NLRP3 are still not available, so it is unclear whether NLRP3 itself can...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Jiang, Hua, He, Hongbin, Chen, Yun, Huang, Wei, Cheng, Jinbo, Ye, Jin, Wang, Aoli, Tao, Jinhui, Wang, Chao, Liu, Qingsong, Jin, Tengchuan, Jiang, Wei, Deng, Xianming, Zhou, Rongbin
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679172/
https://ncbi.nlm.nih.gov/pubmed/29021150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171419
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