In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand

Despite their exceptional capacity for transgene delivery ex vivo, lentiviral (LV) vectors have been slow to demonstrate clinical utility in the context of in vivo applications. Unresolved safety concerns related to broad LV vector tropism have limited LV vectors to ex vivo applications. Here, we re...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Argaw, Takele, Marino, Michael P., Timmons, Andrew, Eldridge, Lindsey, Takeda, Kazuyo, Li, Pingjuan, Kwilas, Anna, Ou, Wu, Reiser, Jakob
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166926/
https://ncbi.nlm.nih.gov/pubmed/34141822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.04.012
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