In vivo targeting of lentiviral vectors pseudotyped with the Tupaia paramyxovirus H glycoprotein bearing a cell-specific ligand

Despite their exceptional capacity for transgene delivery ex vivo, lentiviral (LV) vectors have been slow to demonstrate clinical utility in the context of in vivo applications. Unresolved safety concerns related to broad LV vector tropism have limited LV vectors to ex vivo applications. Here, we re...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Argaw, Takele, Marino, Michael P., Timmons, Andrew, Eldridge, Lindsey, Takeda, Kazuyo, Li, Pingjuan, Kwilas, Anna, Ou, Wu, Reiser, Jakob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166926/
https://ncbi.nlm.nih.gov/pubmed/34141822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.04.012
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