LXR directly regulates glycosphingolipid synthesis and affects human CD4+ T cell function

The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including lipid metabolism, is a crucial step in T cell activation. Here, we explored the role of LXR-regulated metabolic processes i...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Waddington, Kirsty E., Robinson, George A., Rubio-Cuesta, Beatriz, Chrifi-Alaoui, Eden, Andreone, Sara, Poon, Kok-Siong, Ivanova, Iveta, Martin-Gutierrez, Lucia, Owen, Dylan M., Jury, Elizabeth C., Pineda-Torra, Inés
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8166169/
https://ncbi.nlm.nih.gov/pubmed/34006637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017394118
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