Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated analysis and engineering of gene regulatory networks (GRNs)...

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Gepubliceerd in:Cell Syst
Hoofdauteurs: Velazquez, Jeremy J., LeGraw, Ryan, Moghadam, Farzaneh, Tan, Yuqi, Kilbourne, Jacquelyn, Maggiore, Joseph C., Hislop, Joshua, Liu, Silvia, Cats, Davy, de Sousa Lopes, Susana M. Chuva, Plaisier, Christopher, Cahan, Patrick, Kiani, Samira, Ebrahimkhani, Mo R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164844/
https://ncbi.nlm.nih.gov/pubmed/33290741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.11.002
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