Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated analysis and engineering of gene regulatory networks (GRNs)...

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書誌詳細
出版年:Cell Syst
主要な著者: Velazquez, Jeremy J., LeGraw, Ryan, Moghadam, Farzaneh, Tan, Yuqi, Kilbourne, Jacquelyn, Maggiore, Joseph C., Hislop, Joshua, Liu, Silvia, Cats, Davy, de Sousa Lopes, Susana M. Chuva, Plaisier, Christopher, Cahan, Patrick, Kiani, Samira, Ebrahimkhani, Mo R.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164844/
https://ncbi.nlm.nih.gov/pubmed/33290741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.11.002
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