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Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids

Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant tissue fates, and a limited subset of cells. Here, we demonstrate that integrated analysis and engineering of gene regulatory networks (GRNs)...

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Dades bibliogràfiques
Publicat a:Cell Syst
Autors principals: Velazquez, Jeremy J., LeGraw, Ryan, Moghadam, Farzaneh, Tan, Yuqi, Kilbourne, Jacquelyn, Maggiore, Joseph C., Hislop, Joshua, Liu, Silvia, Cats, Davy, de Sousa Lopes, Susana M. Chuva, Plaisier, Christopher, Cahan, Patrick, Kiani, Samira, Ebrahimkhani, Mo R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164844/
https://ncbi.nlm.nih.gov/pubmed/33290741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.11.002
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