Deficiency in nebulin repeats of sarcomeric nebulette is detrimental for cardiomyocyte tolerance to exercise and biomechanical stress

The actin-binding sarcomeric nebulette (NEBL) protein provides efficient contractile flexibility via interaction with desmin intermediate filaments. NEBL gene mutations affecting the nebulin repeat (NR) domain are known to induce cardiomyopathy. The study aimed to explore the roles of NEBL in exerci...

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Détails bibliographiques
Publié dans:Am J Physiol Heart Circ Physiol
Auteurs principaux: Vejandla, Ramona M., Orgil, Buyan-Ochir, Alberson, Neely R., Li, Ning, Munkhsaikhan, Undral, Khuchua, Zaza, Martherus, Ruben, Azeloglu, Evren U., Xu, Fuyi, Lu, Lu, Towbin, Jeffrey A., Purevjav, Enkhsaikhan
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163647/
https://ncbi.nlm.nih.gov/pubmed/33861145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00732.2020
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