Deficiency in nebulin repeats of sarcomeric nebulette is detrimental for cardiomyocyte tolerance to exercise and biomechanical stress

The actin-binding sarcomeric nebulette (NEBL) protein provides efficient contractile flexibility via interaction with desmin intermediate filaments. NEBL gene mutations affecting the nebulin repeat (NR) domain are known to induce cardiomyopathy. The study aimed to explore the roles of NEBL in exerci...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Vejandla, Ramona M., Orgil, Buyan-Ochir, Alberson, Neely R., Li, Ning, Munkhsaikhan, Undral, Khuchua, Zaza, Martherus, Ruben, Azeloglu, Evren U., Xu, Fuyi, Lu, Lu, Towbin, Jeffrey A., Purevjav, Enkhsaikhan
Format: Artigo
Language:Inglês
Published: American Physiological Society 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163647/
https://ncbi.nlm.nih.gov/pubmed/33861145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00732.2020
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