Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function

Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors. Small molecule tyros...

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Pubblicato in:Am J Physiol Cell Physiol
Autori principali: Zheng, Tony J., Lofurno, Elizabeth R., Melrose, Alexander R., Lakshmanan, Hari Hara Sudhan, Pang, Jiaqing, Phillips, Kevin G., Fallon, Meghan E., Kohs, Tia C. L., Ngo, Anh T. P., Shatzel, Joseph J., Hinds, Monica T., McCarty, Owen J. T., Aslan, Joseph E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163578/
https://ncbi.nlm.nih.gov/pubmed/33689480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00296.2020
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