Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function

Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors. Small molecule tyros...

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Publicado en:Am J Physiol Cell Physiol
Main Authors: Zheng, Tony J., Lofurno, Elizabeth R., Melrose, Alexander R., Lakshmanan, Hari Hara Sudhan, Pang, Jiaqing, Phillips, Kevin G., Fallon, Meghan E., Kohs, Tia C. L., Ngo, Anh T. P., Shatzel, Joseph J., Hinds, Monica T., McCarty, Owen J. T., Aslan, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163578/
https://ncbi.nlm.nih.gov/pubmed/33689480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00296.2020
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