Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function

Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors. Small molecule tyros...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Zheng, Tony J., Lofurno, Elizabeth R., Melrose, Alexander R., Lakshmanan, Hari Hara Sudhan, Pang, Jiaqing, Phillips, Kevin G., Fallon, Meghan E., Kohs, Tia C. L., Ngo, Anh T. P., Shatzel, Joseph J., Hinds, Monica T., McCarty, Owen J. T., Aslan, Joseph E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163578/
https://ncbi.nlm.nih.gov/pubmed/33689480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00296.2020
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