Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function

Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (GPVI) and GPIIb/IIIa receptors. Small molecule tyros...

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Bibliografske podrobnosti
izdano v:Am J Physiol Cell Physiol
Main Authors: Zheng, Tony J., Lofurno, Elizabeth R., Melrose, Alexander R., Lakshmanan, Hari Hara Sudhan, Pang, Jiaqing, Phillips, Kevin G., Fallon, Meghan E., Kohs, Tia C. L., Ngo, Anh T. P., Shatzel, Joseph J., Hinds, Monica T., McCarty, Owen J. T., Aslan, Joseph E.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163578/
https://ncbi.nlm.nih.gov/pubmed/33689480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00296.2020
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