A combination of cyclophosphamide and interleukin-2 allows CD4(+) T cells converted to Tregs to control scurfy syndrome

Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by mutations in forkhead box P3 (FOXP3), which lead to the loss of function of regulatory T cells (Tregs) and the development of autoimmune manifestations early in life. The selective induction of a Treg program...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Delville, Marianne, Bellier, Florence, Leon, Juliette, Klifa, Roman, Lizot, Sabrina, Vinçon, Hélène, Sobrino, Steicy, Thouenon, Romane, Marchal, Armance, Garrigue, Alexandrine, Olivré, Juliette, Charbonnier, Soëli, Lagresle-Peyrou, Chantal, Amendola, Mario, Schambach, Axel, Gross, David, Lamarthée, Baptiste, Benoist, Christophe, Zuber, Julien, André, Isabelle, Cavazzana, Marina, Six, Emmanuelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Gene Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163490/
https://ncbi.nlm.nih.gov/pubmed/33545713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009187
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