A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

Several obstacles to the production, expansion and genetic modification of immunotherapeutic T cells in vitro have restricted the widespread use of T-cell immunotherapy. In the context of HSCT, delayed naïve T-cell recovery contributes to poor outcomes. A novel approach to overcome the major limitat...

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Pubblicato in:Cell Mol Immunol
Autori principali: Moirangthem, Ranjita Devi, Ma, Kuiying, Lizot, Sabrina, Cordesse, Anne, Olivré, Juliette, de Chappedelaine, Corinne, Joshi, Akshay, Cieslak, Agata, Tchen, John, Cagnard, Nicolas, Asnafi, Vahid, Rausell, Antonio, Simons, Laura, Zuber, Julien, Taghon, Tom, Staal, Frank J. T., Pflumio, Françoise, Six, Emmanuelle, Cavazzana, Marina, Lagresle-Peyrou, Chantal, Soheili, Tayebeh, André, Isabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245454/
https://ncbi.nlm.nih.gov/pubmed/34117371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-021-00706-8
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