A Nontoxic Transduction Enhancer Enables Highly Efficient Lentiviral Transduction of Primary Murine T Cells and Hematopoietic Stem Cells

Lentiviral vectors have emerged as an efficient, safe therapeutic tool for gene therapy based on hematopoietic stem cells (HSCs) or T cells. However, the monitoring of transduced cells in preclinical models remains challenging because of the inefficient transduction of murine primary T cells with le...

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Publicado en:Mol Ther Methods Clin Dev
Main Authors: Delville, Marianne, Soheili, Tayebeh, Bellier, Florence, Durand, Amandine, Denis, Adeline, Lagresle-Peyrou, Chantal, Cavazzana, Marina, Andre-Schmutz, Isabelle, Six, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125771/
https://ncbi.nlm.nih.gov/pubmed/30191160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.08.002
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