A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction

Reduction sensitive linkers (RSLs) have the potential to transform the field of drug delivery due to their ease of use and selective cleavage in intracellular environments. However, despite their compelling attributes, developing reduction sensitive self-immolative linkers for aliphatic amines has b...

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Veröffentlicht in:Chem Sci
Hauptverfasser: He, Maomao, Li, Jie, Han, Hesong, Borges, Clarissa Araujo, Neiman, Gabriel, Røise, Joachim Justad, Hadaczek, Piotr, Mendonsa, Rima, Holm, Victoria R., Wilson, Ross C., Bankiewicz, Krystof, Zhang, Yumiao, Sadlowski, Corinne M., Healy, Kevin, Riley, Lee W., Murthy, Niren
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163433/
https://ncbi.nlm.nih.gov/pubmed/34123152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc00929f
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