FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity

The idiosyncratic characteristics and severity of acetaminophen (APAP) overdose-induced hepatotoxicity render identifying the predisposing factors and mechanisms of APAP-induced liver toxicity necessary and urgent. Farnesoid X receptor (FXR) controls bile acid homeostasis and modulates the progressi...

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書目詳細資料
發表在:Toxicol Sci
Main Authors: Yan, Tingting, Yan, Nana, Wang, Hong, Yagai, Tomoki, Luo, Yuhong, Takahashi, Shogo, Zhao, Min, Krausz, Kristopher W, Wang, Guangji, Hao, Haiping, Gonzalez, Frank J
格式: Artigo
語言:Inglês
出版: Oxford University Press 2021
主題:
Molecular, Biochemical, and Systems Toxicology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8163055/
https://ncbi.nlm.nih.gov/pubmed/33662127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfab027
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