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The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes
DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A. DNMT3A has a PWWP domain, which recognizes H3K36me2/3, an...
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| 出版年: | PLoS Genet |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8162659/ https://ncbi.nlm.nih.gov/pubmed/34048432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009570 |
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