Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos

The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was previously shown that oocyte-derived DNMT1 (a maintenance methyltransferase) is essential for maintaining and propagating CG methylation at imprint...

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Pubblicato in:PLoS Genet
Autori principali: Maenohara, Shoji, Unoki, Motoko, Toh, Hidehiro, Ohishi, Hiroaki, Sharif, Jafar, Koseki, Haruhiko, Sasaki, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643148/
https://ncbi.nlm.nih.gov/pubmed/28976982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007042
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