Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

Elucidating how and to what extent CpG islands (CGIs) are methylated in germ cells is essential to understand genomic imprinting and epigenetic reprogramming1-3. Here, we present the first integrated epigenomic analysis of mammalian oocytes, identifying over a thousand CGIs methylated in mature oocy...

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Hlavní autoři: Smallwood, Sébastien A., Tomizawa, Shin-ichi, Krueger, Felix, Ruf, Nico, Carli, Natasha, Segonds-Pichon, Anne, Sato, Shun, Hata, Kenichiro, Andrews, Simon R., Kelsey, Gavin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146050/
https://ncbi.nlm.nih.gov/pubmed/21706000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.864
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