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Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos
The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was previously shown that oocyte-derived DNMT1 (a maintenance methyltransferase) is essential for maintaining and propagating CG methylation at imprint...
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| Publié dans: | PLoS Genet |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5643148/ https://ncbi.nlm.nih.gov/pubmed/28976982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007042 |
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