The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes

DNA methylation at CG sites is important for gene regulation and embryonic development. In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A. DNMT3A has a PWWP domain, which recognizes H3K36me2/3, an...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Kibe, Kanako, Shirane, Kenjiro, Ohishi, Hiroaki, Uemura, Shuhei, Toh, Hidehiro, Sasaki, Hiroyuki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162659/
https://ncbi.nlm.nih.gov/pubmed/34048432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009570
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