Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

BACKGROUND: Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) effectively reduces bone resorption and stimulates bone formation, which can inc...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Sun, Qi, Tian, Fa-Ming, Liu, Fang, Fang, Jia-Kang, Hu, Yun-Peng, Lian, Qiang-Qiang, Zhou, Zhuang, Zhang, Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161944/
https://ncbi.nlm.nih.gov/pubmed/34049577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02525-8
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