Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

BACKGROUND: Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) effectively reduces bone resorption and stimulates bone formation, which can inc...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Arthritis Res Ther
Autori principali: Sun, Qi, Tian, Fa-Ming, Liu, Fang, Fang, Jia-Kang, Hu, Yun-Peng, Lian, Qiang-Qiang, Zhou, Zhuang, Zhang, Liu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161944/
https://ncbi.nlm.nih.gov/pubmed/34049577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02525-8
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi