Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats

BACKGROUND: Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) effectively reduces bone resorption and stimulates bone formation, which can inc...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Sun, Qi, Tian, Fa-Ming, Liu, Fang, Fang, Jia-Kang, Hu, Yun-Peng, Lian, Qiang-Qiang, Zhou, Zhuang, Zhang, Liu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161944/
https://ncbi.nlm.nih.gov/pubmed/34049577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02525-8
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