Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats

BACKGROUND: Adjacent segmental intervertebral disk degeneration (ASDD) is a major complication secondary to lumbar fusion. Although ASSD pathogenesis remains unclear, the primary cause of intervertebral disk degeneration (IVDD) development is apoptosis of nucleus pulposus (NP). Raloxifene (RAL) coul...

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Detalhes bibliográficos
Publicado no:J Orthop Surg Res
Main Authors: Sun, Qi, Nan, Xin-Yu, Tian, Fa-Ming, Liu, Fang, Ping, Shao-Hua, Zhou, Zhuang, Zhang, Liu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188785/
https://ncbi.nlm.nih.gov/pubmed/34107971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13018-021-02504-4
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