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Structural impact of GTP binding on downstream KRAS signaling
Oncogenic RAS proteins, involved in ∼30% of human tumors, are molecular switches of various signal transduction pathways. Here we apply a new protocol for the NMR study of KRAS in its (inactive) GDP- and (activated) GTP-bound form, allowing a comprehensive analysis of the backbone dynamics of its WT...
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| 出版年: | Chem Sci |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Royal Society of Chemistry
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8161693/ https://ncbi.nlm.nih.gov/pubmed/34094198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03441j |
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