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(1)H, (15)N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH

K-Ras protein is a membrane-bound small GTPase acting as a molecular switch. It plays a key role in many signal transduction pathways regulating cell proliferation, differentiation, survival, etc. It alternates between its GTP-bound active and the GDP-bound inactive conformers regulated by guanine n...

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Detalhes bibliográficos
Publicado no:Biomol NMR Assign
Main Authors: Pálfy, Gyula, Vida, István, Perczel, András
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069925/
https://ncbi.nlm.nih.gov/pubmed/31468366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-019-09909-7
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