A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors

SIMPLE SUMMARY: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in high-grade chondrosarcoma, high-grade glioma and intrahepatic cholangiocarcinoma. Due to the lack of effective treatment options, these aggressive types of cancer have a dismal outcome. The metabolism of IDH1-mutated ca...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Khurshed, Mohammed, Molenaar, Remco J., van Linde, Myra E., Mathôt, Ron A., Struys, Eduard A., van Wezel, Tom, van Noorden, Cornelis J. F., Klümpen, Heinz-Josef, Bovée, Judith V. M. G., Wilmink, Johanna W.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161333/
https://ncbi.nlm.nih.gov/pubmed/34069550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102474
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