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Wild-type and mutated IDH1/2 enzymes and therapy responses
Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of d-2-hydroxyglutarate. In various...
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| Vydáno v: | Oncogene |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5895605/ https://ncbi.nlm.nih.gov/pubmed/29367755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0077-z |
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