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Wild-type and mutated IDH1/2 enzymes and therapy responses

Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the development and/or progression of various types of cancer due to supraphysiological production of d-2-hydroxyglutarate. In various...

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Bibliografische gegevens
Gepubliceerd in:Oncogene
Hoofdauteurs: Molenaar, Remco J., Maciejewski, Jaroslaw P., Wilmink, Johanna W., van Noorden, Cornelis J. F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895605/
https://ncbi.nlm.nih.gov/pubmed/29367755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0077-z
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