IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity

Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1(MUT)) enzymes consume NADPH to produce d-2-hydroxyglutarate (d-2HG) resultin...

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Vydáno v:FASEB J
Hlavní autoři: Khurshed, Mohammed, Aarnoudse, Niels, Hulsbos, Renske, Hira, Vashendriya V. V., van Laarhoven, Hanneke W. M., Wilmink, Johanna W., Molenaar, Remco J., van Noorden, Cornelis J. F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2018
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181637/
https://ncbi.nlm.nih.gov/pubmed/29879375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800547R
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