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IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1(MUT)) enzymes consume NADPH to produce d-2-hydroxyglutarate (d-2HG) resultin...
Gardado en:
| Publicado en: | FASEB J |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6181637/ https://ncbi.nlm.nih.gov/pubmed/29879375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800547R |
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