IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity

Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1(MUT)) enzymes consume NADPH to produce d-2-hydroxyglutarate (d-2HG) resultin...

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Foilsithe in:FASEB J
Main Authors: Khurshed, Mohammed, Aarnoudse, Niels, Hulsbos, Renske, Hira, Vashendriya V. V., van Laarhoven, Hanneke W. M., Wilmink, Johanna W., Molenaar, Remco J., van Noorden, Cornelis J. F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Federation of American Societies for Experimental Biology 2018
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181637/
https://ncbi.nlm.nih.gov/pubmed/29879375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800547R
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