IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity

Isocitrate dehydrogenase (IDH1)-1 is mutated in various types of human cancer, and the presence of this mutation is associated with improved responses to irradiation and chemotherapy in solid tumor cells. Mutated IDH1 (IDH1(MUT)) enzymes consume NADPH to produce d-2-hydroxyglutarate (d-2HG) resultin...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Khurshed, Mohammed, Aarnoudse, Niels, Hulsbos, Renske, Hira, Vashendriya V. V., van Laarhoven, Hanneke W. M., Wilmink, Johanna W., Molenaar, Remco J., van Noorden, Cornelis J. F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181637/
https://ncbi.nlm.nih.gov/pubmed/29879375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800547R
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