Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K(2(20)), on All-Trans Retinoic Acid-Resistant HL60 Cell Line

The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin K(2(20))), used for osteoporosis treatment, does...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pharmaceutics
Auteurs principaux: Yamakawa, Hirofumi, Setoguchi, Shuichi, Goto, Shotaro, Watase, Daisuke, Terada, Kazuki, Nagata-Akaho, Nami, Toki, Erina, Koga, Mitsuhisa, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161027/
https://ncbi.nlm.nih.gov/pubmed/34065416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050758
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