Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term chemopreventive agent is strongly in demand. Menahydroquinone-4 (MKH) is an active form of menaquinone-4 (MK-4, vitamin K(2)) that is involve...

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Publicado en:Molecules
Main Authors: Setoguchi, Shuichi, Watase, Daisuke, Matsunaga, Kazuhisa, Yamakawa, Hirofumi, Goto, Shotaro, Terada, Kazuki, Ohe, Kenji, Enjoji, Munechika, Karube, Yoshiharu, Takata, Jiro
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100056/
https://ncbi.nlm.nih.gov/pubmed/30013007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071738
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