Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kinase (BTK) PROTAC compounds, we show herein efficient...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Shorer Arbel, Yamit, Katz, Ben-Zion, Gabizon, Ronen, Shraga, Amit, Bronstein, Yotam, Kamdjou, Talia, Globerson Levin, Anat, Perry, Chava, Avivi, Irit, London, Nir, Herishanu, Yair
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159153/
https://ncbi.nlm.nih.gov/pubmed/34055615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.646971
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars