Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kinase (BTK) PROTAC compounds, we show herein efficient...

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Bibliografske podrobnosti
izdano v:Front Oncol
Main Authors: Shorer Arbel, Yamit, Katz, Ben-Zion, Gabizon, Ronen, Shraga, Amit, Bronstein, Yotam, Kamdjou, Talia, Globerson Levin, Anat, Perry, Chava, Avivi, Irit, London, Nir, Herishanu, Yair
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Oncology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159153/
https://ncbi.nlm.nih.gov/pubmed/34055615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.646971
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