Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kinase (BTK) PROTAC compounds, we show herein efficient...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Shorer Arbel, Yamit, Katz, Ben-Zion, Gabizon, Ronen, Shraga, Amit, Bronstein, Yotam, Kamdjou, Talia, Globerson Levin, Anat, Perry, Chava, Avivi, Irit, London, Nir, Herishanu, Yair
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8159153/
https://ncbi.nlm.nih.gov/pubmed/34055615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.646971
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