AGO2 promotes tumor progression in KRAS-driven mouse models of non–small cell lung cancer

Lung cancer is the deadliest malignancy in the United States. Non–small cell lung cancer (NSCLC) accounts for 85% of cases and is frequently driven by activating mutations in the gene encoding the KRAS GTPase (e.g., KRASG12D). Our previous work demonstrated that Argonaute 2 (AGO2)—a component of the...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Tien, Jean Ching-Yi, Chugh, Seema, Goodrum, Andrew E., Cheng, Yunhui, Mannan, Rahul, Zhang, Yuping, Wang, Lisha, Dommeti, Vijaya L., Wang, Xiaoming, Xu, Alice, Hon, Jennifer, Kenum, Carson, Su, Fengyun, Wang, Rui, Cao, Xuhong, Shankar, Sunita, Chinnaiyan, Arul M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157917/
https://ncbi.nlm.nih.gov/pubmed/33972443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026104118
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