Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response

Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical behavior. Delineating the cells of origin for different RCC subtypes will provide mechanistic insights into their diverse pathobio...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Zhang, Yuping, Narayanan, Sathiya P., Mannan, Rahul, Raskind, Gregory, Wang, Xiaoming, Vats, Pankaj, Su, Fengyun, Hosseini, Noshad, Cao, Xuhong, Kumar-Sinha, Chandan, Ellison, Stephanie J., Giordano, Thomas J., Morgan, Todd M., Pitchiaya, Sethuramasundaram, Alva, Ajjai, Mehra, Rohit, Cieslik, Marcin, Dhanasekaran, Saravana M., Chinnaiyan, Arul M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8214680/
https://ncbi.nlm.nih.gov/pubmed/34099557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103240118
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