An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) formation yet prevents progression to pancreatic duct...

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Publicat a:Nat Commun
Autors principals: Shankar, Sunita, Tien, Jean Ching-Yi, Siebenaler, Ronald F., Chugh, Seema, Dommeti, Vijaya L., Zelenka-Wang, Sylvia, Wang, Xiao-Ming, Apel, Ingrid J., Waninger, Jessica, Eyunni, Sanjana, Xu, Alice, Mody, Malay, Goodrum, Andrew, Zhang, Yuping, Tesmer, John J., Mannan, Rahul, Cao, Xuhong, Vats, Pankaj, Pitchiaya, Sethuramasundaram, Ellison, Stephanie J., Shi, Jiaqi, Kumar-Sinha, Chandan, Crawford, Howard C., Chinnaiyan, Arul M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272436/
https://ncbi.nlm.nih.gov/pubmed/32499547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16309-2
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