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A designed second-sphere hydrogen-bond interaction that critically influences the O–O bond activation for heterolytic cleavage in ferric iron–porphyrin complexes

Heme hydroperoxidases catalyze the oxidation of substrates by H(2)O(2). The catalytic cycle involves the formation of a highly oxidizing species known as Compound I, resulting from the two-electron oxidation of the ferric heme in the active site of the resting enzyme. This high-valent intermediate i...

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Détails bibliographiques
Publié dans:Chem Sci
Auteurs principaux: Bhunia, Sarmistha, Rana, Atanu, Dey, Somdatta Ghosh, Ivancich, Anabella, Dey, Abhishek
Format: Artigo
Langue:Inglês
Publié: The Royal Society of Chemistry 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157560/
https://ncbi.nlm.nih.gov/pubmed/34084327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04388h
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