A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage

OBJECTIVE: Studies show that phosphodiesterase-V (PDE-V) inhibition reduces cerebral vasospasm (CVS) and improves outcomes after experimental subarachnoid hemorrhage (SAH). This study was performed to investigate the safety and effect of sildenafil (an FDA-approved PDE-V inhibitor) on angiographic C...

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Dades bibliogràfiques
Publicat a:J Neurosurg
Autors principals: Washington, Chad W., Derdeyn, Colin P., Dhar, Rajat, Arias, Eric J., Chicoine, Michael R., Cross, DeWitte T., Dacey, Ralph G., Han, Byung Hee, Moran, Christopher J., Rich, Keith M., Vellimana, Ananth K., Zipfel, Gregory J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157481/
https://ncbi.nlm.nih.gov/pubmed/26314998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2015.2.JNS142752
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