A Phase I proof-of-concept and safety trial of sildenafil to treat cerebral vasospasm following subarachnoid hemorrhage

OBJECTIVE: Studies show that phosphodiesterase-V (PDE-V) inhibition reduces cerebral vasospasm (CVS) and improves outcomes after experimental subarachnoid hemorrhage (SAH). This study was performed to investigate the safety and effect of sildenafil (an FDA-approved PDE-V inhibitor) on angiographic C...

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Detalhes bibliográficos
Publicado no:J Neurosurg
Main Authors: Washington, Chad W., Derdeyn, Colin P., Dhar, Rajat, Arias, Eric J., Chicoine, Michael R., Cross, DeWitte T., Dacey, Ralph G., Han, Byung Hee, Moran, Christopher J., Rich, Keith M., Vellimana, Ananth K., Zipfel, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157481/
https://ncbi.nlm.nih.gov/pubmed/26314998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2015.2.JNS142752
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