Phosphodiesterase 5 Inhibition Attenuates Cerebral Vasospasm and Improves Functional Recovery after Experimental Subarachnoid Hemorrhage

BACKGROUND: Cerebral vasospasm is an independent predictor of poor outcome after subarachnoid hemorrhage (SAH). The nitric oxide-cyclic GMP (NO-cGMP) vasodilatory pathway is strongly implicated in its pathophysiology. Preliminary studies suggest that phosphodiesterase 5 (PDE5) – an enzyme that degra...

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Vydáno v:Neurosurgery
Hlavní autoři: Han, Byung Hee, Vellimana, Ananth Kesav, Zhou, Meng-Liang, Milner, Eric, Zipfel, Gregory Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288819/
https://ncbi.nlm.nih.gov/pubmed/21796010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0b013e31822ec2b0
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