Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease

Inside cells, the immunomodulator methotrexate (MTX) undergoes the addition of glutamates to form methotrexate polyglutamates (MTX-Glu)—promising biomarkers of systemic exposure and treatment response to MTX in rheumatology. MTX-Glu are underexplored in Inflammatory Bowel Disease (IBD), with no data...

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Bibliographic Details
Published in:Pharmaceuticals (Basel)
Main Authors: Morrow, Ryan, Funk, Ryan, Becker, Mara, Sherman, Ashley, Van Haandel, Leon, Hudson, Taina, Casini, Rebecca, Shakhnovich, Valentina
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8156207/
https://ncbi.nlm.nih.gov/pubmed/34069031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14050463
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