Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation, parabiosis, plasma transfer, exercise, calorie restriction, and aging mutant mice to understand the effects of...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Ho, Theodore T., Dellorusso, Paul V., Verovskaya, Evgenia V., Bakker, Sietske T., Flach, Johanna, Smith, Lucas K., Ventura, Patrick B., Lansinger, Olivia M., Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A., Villeda, Saul A., Passegué, Emmanuelle
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155813/
https://ncbi.nlm.nih.gov/pubmed/34032859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210223
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