Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of (11)C-Labeled ALK2 Inhibitors

[Image: see text] Mutations in the gene encoding activin receptor-like kinase 2 (ALK2) are implicated in the pathophysiology of a pediatric brainstem cancer, diffuse intrinsic pontine glioma (DIPG). Inhibitors of ALK2 that cross the blood–brain barrier have been proposed as a method of treatment for...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Murrell, Emily, Tong, Junchao, Smil, David, Kiyota, Taira, Aman, Ahmed M., Isaac, Methvin B., Watson, Iain D. G., Vasdev, Neil
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155239/
https://ncbi.nlm.nih.gov/pubmed/34055235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00127
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